Why Redox Signaling will Transform Medical Science

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As medical science advances, it appears to become more and more difficult to find treatments that are not harmful to certain parts the body and yet offer real benefits to the patient. Normally, after billions of dollars of research, the treatments that promise the best results often come along with long lists of side effects that may be much more detrimental to some people than the original medical condition itself. Medical science compensates by conducting billions of dollars of research to find treatments for the undesirable side effects. While such efforts keep medical researchers busy and pharmaceutical companies profitable, at some point these advances need to be weighed against the needs of the patient. In general, the cost of medical treatment is escalating and results can still be quite detrimental on several fronts.

Looking for potential cost-effective treatments that have minimal negative side effects would seem to offer the best remedy. As our understanding of biology advances, it is also becoming obvious that our body is only built to take into itself the things that grow in and around us in nature, everything else is treated by the body like unwanted garbage. Processed chemicals, engineered molecules and highly concentrated specialized extracts may fit the model of current food and medical industry, but they have the tendency to fight against basic biology and produce negative side effects. Naturally occurring biocompatible remedies, on the other hand, fit well with our basic biology, yet they might not fit well with the current medical industry and philosophy.

As medical science starts to transform toward seriously studying inexpensive biocompatible natural substances as treatments, there is finally much hope for the discovery of ideal cost-effective remedies. Funding the research for such remedies remains an economic issue. The incentive is not there; large profits cannot be made in our current medical industry from inexpensive easy-to-find-and-produce natural solutions no matter how effective they may be as treatments. It still appears to be the tendency of medical professionals to doubt that natural solutions are real solutions, even as they are witnessing many of their patients get sicker and sicker under current treatments and lose hope for the future. In general, they also tend to ignore nutrition, exercise, hydration, positive attitude and sleep as key players.

Redox Signaling is one of the best-positioned technologies that promises to lead the transformation of medical science. It has all the right stuff. Redox signaling is a fundamental process inside our body that reduces and oxidizes (redox’s) the salt water and biomolecules inside us, it plays a fundamental role in cellular communication, helping the cells to optimally do what they are already programmed to do. It helps the body locate the damaged cells inside us, kill them or replace them and to better regenerate healthy tissue. Balanced compositions of reactive oxygen species (ROS) have been found that are relatively inexpensive to produce, have shown no negative side effects after 20 years of studies and can actually enhance the ability of the body’s antioxidants to protect healthy normal cells from damage and accelerate normal cellular regeneration.

Such redox signaling molecules come in a clear liquid form and can be ingested, placed in the eyes, ears, nose, breathed into the lungs, placed anywhere inside or outside the body without causing harm of themselves. They can be used in gels to be placed on the skin, they can be used as irrigation. They stop bleeding, sterilize the tissues within seconds, enhance antioxidants, increase hormone reception, open cell communication channels, increase reducing agents (NRF2, antioxidants), decrease oxidative stress and decrease oxidized cholesterol, decrease inflammation and irritation, and reduce germs and pain among other things. Redox signaling technologies can also be used in conjunction with other promising technologies like stem cells, nutritional and mineral therapies, exercise programs (to reduce muscle damage and pain) and detoxification therapies. It is a truly versatile and fundamental natural technology that stands as an example of what could lie ahead of us in the future of medical science.

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A Journey of Discovery Published

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Today marks a milestone in my own personal journey of discovery.  I appreciate the freedom I have to express this journey, knowledge and vision in words so that others can profit thereby.  I appreciate the chance to do so, as time permits, here on this blogsite.  My new book has “hit the bookstands” in Amazon today.  To take a look, you can search “Amazon Kindle” books for “redox signaling”.  I will also place the link below, if permitted.  I ever hope that the truths of nature and science will be heard and understood.

 

 

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Book Excerpt — Vast Potential Applications

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Vast Potential Applications – Expansive, Beautiful Terrain

With new insight opened to me by the burgeoning field of redox signaling, I realized that these same molecules helped the immune system to find and repair or destroy damaged cells. In fact, as outlined above, they participate in multiple pathways of tissue regeneration, hormonal reception, oxidative stress response, signaling gene expression and so forth. Each new insight opened up more to my view until before my eyes was laid a nearly endless landscape of possibility, extending far off into the horizon. This terrain was just starting to be explored and had pathways that led into virtually all areas of medical science. Such was my fascination that I immediately wished to share this experience with my colleagues. I went back down the trail, marking the way, in hopes that I could convince someone to come back up the trail with me and see what I had just seen and maybe help me explore it.

Invitation for Collaboration – You have just got to see this!

Some of the first people that I invited to explore the trail were those that had themselves blazed some of the trail; researchers that had participated or done some of the earlier studies on this work. As expected, they were already involved in other work and did not always have the time or ambition to take off work to go and explore more of this trail with me. A few said they would come but, of course, they expected some sort an agreement. The same thought kept repeating in my mind, “good science requires good business”. Unfortunately, I felt that I did not have much of a hand in the business aspects at the time, and often felt a hesitance to get too involved with the business. Thus I was reliant on those that were more experienced in building a business and the management teams that controlled the intellectual property.

We were able to get some limited funding in order to get a senior researcher at a national lab involved. This researcher was able to do some fundamental research with lung endothelial cell cultures and opened up several other vistas to view. He was the one to discover that this Redox composition has the effect of increasing antioxidant efficiencies and that it activates the NRF2 pathways, with all that that implies (as already discussed in this book). He also found that it drastically increases death rates in damaged cells and enhances TNF-alpha action to kill damaged cells and yet has only protective effects on normal healthy cells. These new results opened much more unexplored terrain to view, including antioxidant activation, oxidative stress reduction, accelerated healing, accelerated detection, and disposal of damaged cells. This aspect is very promising; the propagation of damaged cells and tissues, as well as slow healing, is responsible for a vast array of health challenges, including aging.  Unfortunately, after a year when funding ran out, so did the possibility of continuing the research.

Third Party Investigation – Sharing the Journey of Discovery

In as much as possible, third party independent laboratories were sought to find researchers to join the journey; laboratories with competent engaged professionals trained in diverse related areas of science and research. At this point, the business management team was closely involved in helping to find and identify the best areas of research to pursue and the best research institutions. Over months of phone calls, contacts, professional reviews, trips to laboratories, contract negotiations, and meetings, we started to find the right people to help us continue forward on the path of discovery. I fondly recall one such trip we made to the middle of an area called “the research triangle” in North Carolina, USA; an area where most of the medical and pharmaceutical research in the United States is done. The North Carolina Research Institute (NCRI) houses a collaboration of researchers from surrounding universities (Chapel Hill, UNC, Duke, Appalachian State, NCS, and others) inside a beautiful billion dollar research campus (NCRC) built by David H. Murdock (of Dole Foods) with the world-class David H Murdock Research Institute (DHMRI). This facility is a shrine to research devoted to advancing health, wellness, quality of life, and longevity. It was there we found a group of researchers specializing in the effects of exercise and other agents on the metabolism.

Over the period of two years, results from studies verified this Redox Composition had broad effects on murine (mouse) and human metabolism. Mice ran 29% longer with this Redox composition in comparison to an unprocessed saltwater solution. In human blood and fluids, hundreds of metabolite concentrations are shifted, indicating changes to the metabolism. There were several follow-up studies to see how this metabolic shift varied with time and conditions. Large human studies again verified safety by monitoring major systems and organs of mature adults. One result, for example, is that this Redox composition appears not to affect beneficial, bacteria inside the gut and reduces oxidative stress in the blood. Studies continue on to find out how this Redox composition works and what it means.

Studies are now being conducted around the world on this Redox composition. For example, in Europe, another research group found that in human skin, surface blood circulation dramatically improved, skin-cell turnover accelerated, cellulite globules shrank, smoothness and color consistency improved. There are also various studies that characterize nature of this Redox composition. Besides funded research, there are also completely independent studies that I know of being done by curious private researchers in universities, institutions, and industry, and probably many more that I do not know of.

Besides the direct research being done on this specific Redox composition, the field of redox biochemistry and redox signaling with other compositions are expanding horizons daily. Some are starting to intersect trails that we are exploring, and the whole terrain is becoming more well-known. Over 100 related peer reviewed journal articles are being published monthly. New trails are being blazed by present and future Nobel laureates and top scientist in all fields of biology. All of these are making inroads to explore the new terrain through a whole new variety of angles. This beautiful virgin landscape is now beholden by thousands of people and I am hoping someday it will be enjoyed by the whole world.

 

 

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Chapter Excerpt: Navigation Map of Pathways

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The Cardiovascular and Pulmonary System – Heart, Lungs, and Blood…

In the cardiovascular and cardiopulmonary system, redox balance is strictly regulated. There are about 5000 mitochondria [producing redox signaling molecules] in every heart cell. As you can imagine, the level of superoxide free radicals (O2*-) and hydrogen peroxide (H2O2) [redox signaling molecules] in heart cells must be carefully regulated and controlled. The heart can never take a break and so redox imbalance and cellular damage in heart tissue must be quickly detected and repaired. The redox signaling networks among heart cells are very efficient. Endothelial layers that line the blood vessels extend these signaling networks to the whole cardiovascular network, sending signals that regulate blood flow, pressure, and needed supplies throughout the whole body, along the whole river of life, in all of our cellular communities, creating a massively complex network analogous to the signaling capacity of our nervous system…

The Digestive System – Mouth, Stomach, and Intestines

In the digestive system, the cell linings in the intestines that process nutrients are exposed to acids, enzymes, toxins, oxidants, physical stress, and all manner of harsh environments. The turnover rate for these types of cells is one of the highest in the body; tens of billions of stomach and intestinal cells are replaced per day. In fact, the entire length of intestines themselves are completely replaced about every 7 days. This continual turnover of cells requires that damaged cells are quickly detected, repaired, or replaced. You can compare the intestinal lining to a “forest” of brush cells where there are frequent redox “smoke signals” sent by the damaged cells indicating “forest fires” that need immediate attention from the emergency responders. If this redox signaling system is not in excellent shape, then potential damage can spread too quickly, causing leaks and gaps that compromise the function of the digestive system…

The Nervous System – Brain, Spine, and Peripheral Nerves

In the nervous system, brain cells are not easily replaced and must be protected. Oxidative stress is the primary reason for nerve cell death, even more so than lack of oxygen. Mental stress and worry, as well as deep thinking, increases brain activity. Heightened brain activity incites a build-up of oxidants or oxidative stress…Oxidative stress triggers seizures and/or other irregularities. Regulation of blood flow through the brain is closely monitored, as the brain needs a constant supply of oxygen and sugars. All of this is regulated by redox signaling networks…Peripheral nerves in the body send pain messages when they are exposed to oxidative stress due to oxidants in the neighborhood. Even more, the redox signaling networks are also very active in helping maintain the balance of the hormonal axes in the brain and nerves (such as the HPA axis) that help keep the emotional balance we need to function. There is no question to the prime importance of the redox signaling networks in the brain. The brain contains most complex signaling network in the body integrally and intricately connected by such signaling networks.

The Endocrine System – The Pituitary, Thyroid, and Adrenals

In the endocrine system, glandular secretions (hormones) are triggered by stress and redox pathways. We have already discussed how important it is to our emotional and physical state to maintain hormonal balance throughout the whole network of the endocrine system. If oxidative stress is the trigger for hormonal secretions and redox signaling regulates oxidative stress, you can imagine the importance of redox signaling to maintain balance in the endocrine system. There is direct evidence that correct redox balance in the vital fluids around our cells also helps lubricate the “windows” and “doors” (receptors) that bring hormonal messages (and insulin) into the cells, which means that smaller numbers of hormones may be needed to do the job, making hormonal regulation lighter and faster and more readily balanced.

The Excretory System – The Skin, Kidneys, and Colon

The tissues of our excretory systems (skin glands, kidneys, colon, etc.) have the unsavory job of sorting through and eliminating the toxic garbage of the body. This requires efficient management of toxic response and extraordinary communication signals between specialized layers of tissue, as well as top-grade protective equipment (antioxidants) to do the job. There is perhaps no other system of the body where redox signaling is more active to maintain the immediate health of the tissues than in the kidneys and intestines. Their specialized layers of tissue are constantly sorting and pushing along the toxic garbage. These toxins cause oxidative stress and cell death due to toxic insult of the tissues. As always, the antioxidants need to be on call to quickly clean up the oxidative stress before it causes any serious damage and repair and replace damaged cells. The oxidative stress itself also helps identify the toxins and helps them to move out through the excretory channels. All these processes require a high level of redox signaling. Toxic stress, in addition, causes the release of certain hormones associated with toxic load. For example, the kidneys will release a hormone called renin when they are under a high toxic stress. Renin is designed to increase the blood pressure needed in order to push the toxins out faster. Of course, water (proper hydration) is always regulated and beneficial to excretory processes…

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Another Excerpt from Final Chapters: Redox Signaling Mediates Everything

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The field of redox signaling is destined to become the field of science that will fuel the greatest medical discoveries in this next century and beyond. The universal signaling systems that exist in the fluids of life, inside every living cell and tissue, the signaling systems that have existed from the inception of life and in all forms of life that have existed or will exist on earth constitute the most fundamental signaling systems in biology. They reveal to us what makes life work on the smallest, most universal level. Redox signaling describes the molecular signaling mechanisms that modify the structure of water, that transmit messages throughout the fundamental fluids of life. The simple, common molecules that initiate and transmit these messages through living fluids are mostly manufactured inside living cells from water (hydrogen and oxygen) and salt (chloride and sodium), and also include a few of most common elements of life (nitrogen, carbon and sulfur). These are the molecules that initiate and mediate the life-sustaining redox signaling pathways throughout all the cells and tissues of our body…

If you are interested in looking up scientific literature in the field of redox signaling, you probably will not find any direct reference under the name of “redox signaling molecules”. I have taken some literary license to create descriptive names – such as “semaphores”, “reductants” and “redox signaling molecules” – that are not commonly used in scientific literature to describe such classifications of molecules. I have attempted to define these literary terms and place the scientific names in parenthesis as much as possible in this book. In order to do literature searches on this group of “redox signaling molecules”, try looking up: Reactive Oxygen Species (ROS), referring to the species of molecules containing oxygen (hydrogen peroxide, superoxide free radical, hypochlorite ion, singlet oxygen). Reactive Nitrogen Species (RNS) refers to species containing nitrogen (Nitric Oxide free radicals and other downstream nitrogen radical cascades). Of course, you can refer to each by its chemical name to get information. For example, google/scholar: “redox signaling hydrogen peroxide”. If you wish to get information on “reductants”, it would be best to search under “electron donors” or “reduced species”…There are literally hundreds of scientific articles being written on this subject every month, representing thousands of months of scientific effort across the world. It is truly marvelous to be living in this day and age where knowledge gained from everywhere in the world is almost instantaneously accessible by anyone with a true desire to know.

Possibly even more important than finding the appropriate vocabulary to express the scientific concepts, the potential applications for these emerging technologies in the health science fields need to find adequate expression. Since redox signaling is active in every cell and tissue, the potential health care applications are universal to all forms of life, cells, tissues, organs, and systems. The cardiovascular system, endocrine system, nervous system, digestive, and excretory systems all heavily rely on these redox signaling pathways to carry out their daily business. The innate immune system requires redox signaling almost more than any other system to detect areas of cellular damage, to assess the situation, to kill the microbes, to shut down damaged cells, and to stimulate regeneration of tissue…

One of the first things that drew me into study the field of redox signaling was the realization that the immune system kills bacteria and viruses almost exclusively by shooting them with an “oxidative burst” containing a composition of many of the redox signaling molecules I was studying. This was of interest to me. Certainly the primary weapon of the immune system must be completely effective against all types of bacteria, viruses, and parasites that exist; otherwise, we would all be subject to mass extinction. The oxidative burst used by the immune system to kill all types of microbes and parasites is a combination of superoxide free radicals (O2*-), hydrogen peroxide (H2O2), and hypochlorite ions (OCl-). These molecules should be somewhat familiar to us at this point. So, at the very least, one possible application of this technology would be to develop an extremely effective and safe disinfectant. Such a disinfectant would use the same “technology” that is used in the immune system to kill microbes and yet be harmless to healthy normal cells….This “redox disinfectant” would be safe and effective for all types of tissues on all such types of multi-cellular life…

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Journey of Discovery into Redox Signaling–Book Excerpts

 

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The major purpose of this book is to give the reader an overarching view of the myriad pathways that exist in living organisms and the amazing complexities of their interaction. At the end of our journey of discovery into redox signaling pathways, one thing is clear: there are a vast amount of pathways carrying signals in our body. Most, if not all of these pathways intersect or are influenced by redox signaling pathways. The redox signaling molecules that participate in these pathways exist in most all of the vital fluids in our body. They are produced as part of metabolic processes (ROS from mitochondria), immune processes (oxidative burst), and redox signaling processes (NADPH complexes), in all types of blood vessels (vasoconstriction/dilation), molecular transport processes (g-protein receptors), and cellular signaling reception processes (endothelial cells). They play essential roles in the innate immune system, endocrine (hormonal) system, nervous system, digestive system, excretory (toxin detection and removal) system, cardiovascular system, and in any system that requires detection, repair, and replacement of damaged cells and tissues, which pretty much includes all of the systems in our body. So the real question should be: “What pathways do they not affect?” These redox signaling molecules form a set of signaling molecules that quite possibly affect the pathways in all areas of the body.

When individually isolated, practically all of these redox signaling molecules (such as hydrogen peroxide, hypochlorite or superoxide) have immediate…effects that has been documented over a century of science…It is difficult to believe that there exists a combination of these redox signaling molecules that even in high concentrations have absolutely no such toxic effects on healthy normal cells, tissues, and systems. And yet, we have discovered such a technology. This electrolyzed saltwater solution, as outlined above, contains most of the ROS components, yet, as a whole behaves much differently than expected from any of its individual components. As we have discussed, this electrolyzed salt water does not activate NF-kapaB pathways or cause inflammation in any measurable degree in normal cells, irrespective of the individual components. However, it does activate NRF2 and increase antioxidant efficiencies in human lung endothelial cells and somehow shifts metabolic profiles in animals and humans. Not only is this unexpected, it is in some sense miraculous and has not been observed before for any other compound.

Given the vast quantity of pathways that these ROS components can alter, the very fact that this electrolyzed Redox solution is relatively inert and very safe when in contact with living tissue needs to be explained and accounted for…Perhaps the only explanation is simply that cells and tissues can easily deal with this Redox solution because it is already in a form that is similar to the endogenous ROS compounds already found in the cells, tissues, and systems. Even adding large amounts of this solution to cells and tissues does not seem to disturb redox equilibrium and homeostasis. This solution can easily be dealt with by the cells and tissues…For those who are truly on a journey of discovery, the observations made so far about this electrolyzed Redox solution represent an expansive horizon of unexplored terrain, stretching outward in all directions. For the first time in history, we have found something that has practically no adverse effects for all types of cells and tissues and yet can directly affect some of the most fundamental redox pathways that have existed in all forms of life since the beginning (of oxidative processes). We have found a remarkable path into the unknown regions of life. There is a certain sense of adventure in not quite knowing what lies around the corner as we continue to explore this expansive wilderness that, for now, seems to have no end.

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Is Pain Good?

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How could we ever say that feeling pain is good? Why do we feel pain? What is the purpose of pain? Could we get by without it? The answers to these questions reveal much wisdom. Let’s use our imagination for a minute, imagine the greatest athlete you know. Can you see this the person’s face? It is 100% probable, that this person has put themselves through hours, weeks and years of painful practice routines to get where they are now. Intuitively we know that. When we stand and cheer them, we also honor the years of discipline needed to succeed. We see stadiums of cheering and sometimes crazy fans, willing to pay stifling amounts, to see athletes perform. Why?

We relate to the pain and sacrifice they paid to succeed, we can almost feel it in some way. Now imagine a list of the salaries of the top-rated athletes. We also realize the importance that society places on their achievement. We say, “No pain, no gain.” Pain is a necessary element that leads to success. Let’s call this type of pain “good pain”.

What about the physical pain we feel in our bodies? Since we don’t “ask for it”, could we still think of this type of pain as “good pain”, the kind that ultimately leads to the successful performance of our physical body? It is tempting to think that the pain we feel inside our bodies is an indication of a failure of some sort, an illness, an injury, a malfunction, a weakness in our system. Is unwanted physical pain something that should be considered as evil, something to be eliminated? If we really understand the reason that physical pain exists, we might want to seriously consider that even unwanted physical pain can be “good pain”, the kind that leads to the ultimate success and triumph of our body.

Several years ago, I was eating some soup and felt a stab of pain on the right side of my gut. Over the next few hours, the pain became so intense that I was afraid that I might lose consciousness, I went to the hospital. They found that the blood supply to a part of my small intestine had become strangled by a fiber of fat, a very rare occurrence. Emergency surgery was needed, they opened me up with a 12-inch incision, explored my intestines, found that part of it had already died, they resected the dead part and put me back together. When the anesthesia wore off, the pain was intense. I was given a “pain pump” that administered morphine at the press of a button I could hold in my hand, this was a gift from an ex-president of the University of Utah (an honored medical doctor and friend that had come to visit me.)

Knowing the real dangers of an extended hospital stay, I really wanted to avoid infection, heal and leave the hospital as quickly as possible. At this point, having an academic knowledge of my body helped. I knew that the pain I felt was indicating where my body was healing and was there to help me avoid reinjury as my abdomen closed. I avoided pressing the morphine button and decided to endure the pain as much as I could. In fact, I focused my mind on the pain and with the mental clarity afforded me, I could know exactly where healing was taking place. As soon as I could, I learned how to scoot to the edge of my bed, the pain directed me as to how fast I could go as I pulled myself into a seated position. I learned to manage all the feeding tubes, IV’s, etc. so I could stand and walk around, pulling all my baggage around with on my IV rack as I went. This exhausted me and I was able to sleep. As a result, my abdomen healed well and I was released from the hospital in three days (4 days following the surgery). I considered the pain to be my friend and that made it much more tolerable.

Physical pain originates from nerve stimulation caused by oxidative stress, in turn, oxidative stress is caused by an excess of oxidants that naturally build up in and around damaged and stressed cells. The natural purpose of oxidative stress is to alert the body to the damage by sending signals (including pain, inflammation, and immune response) that activate the genes in the cells that motivate the healing processes, repair the damage which ultimately removes the source of stress and damage. The signaling generated by oxidation is called redox signaling (signaling through reduction/oxidation). When the cells are successful in their repair efforts, redox balance in the cells are restored and the pain and inflammation subside as the tissues are rebuilt, better than new.

If even intense physical pain can be a tool for healing, then what then could be considered as “bad pain”? Since pain is an indication of where the body is healing, we can define “bad pain” as the type that does not serve as a tool to ultimately lead us to the healing and success of the body. The chronic, persistent pain that indicates that something is wrong, but the body is not strong enough to activate the healing response to the extent needed to repair the damage. Things can go bad, though, when the body is not able, for some reason, to complete this healing process. Chronic persistent oxidative stress causes even more damage (excess oxidants can be harmful), such damage causes more oxidative stress, stimulating even more stress and oxidation, and a downward cycle ensues. Such processes contribute to chronic problems, such as chronic inflammation, arthritis, lupus, irritable bowel, allergic response, fibromyalgia, autoimmune disorders, and even emotional and mental problems, and so on.

The only way to turn off the oxidative stress and pain and start healing in these instances is to eliminate the stressor, if possible, and then turn off the oxidative stress cycle that will allow the tissues to heal naturally. Methods to turn off these inflammatory signals in our bodies are available to us if we choose to use them.

Antioxidants from foods, vitamin C, redox-balanced supplements (shown to reduce oxidative stress and enhance redox signaling), eating leafy green vegetables, decreasing sugars and carbohydrates, physical exercise, adequate hydration, sleep, relief from chronic emotional stressors are all accessible methods to turn off the inflammatory genes and start healthy tissue regeneration.

The mind is a wonderfully potent tool. Try this: in a quiet place relax your body, focus your mind on the bottom of your feet, you may become aware of tingling sensations or “dull pain” that indicates places where your feet are repairing themselves. Now slowly move your focus to your calves, knees, thighs, abdomen, back, lungs (breathing), arms, neck, jaw, teeth, and so on, noting any sensations you feel. You will find that you can receive messages from almost every part of your body about its condition and how it is healing.

By focusing on the signals coming from various parts of the body you can also stimulate healing. I do this exercise to help relieve my back pain on long flights and help me sleep. I focus on my back, “listen” to the places where my back hurts, make subtle adjustments to relieve the stress on my spine that helps center my weight and reduce the pain, and focus on my breathing. I find that with this focus, I can relax and even sleep on long flights. It feels like magic.

Pain is there to motivate us to make the adjustments necessary to heal.

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